Bibliography: #T53MLBK8

key	T53MLBK8
title	Intermittent Fasting Regimes Reduce Gingival Inflammation : A Three-Arm Clinical Trial
author	Pappe, C. L.; Maetschker, J.; Dujardin, S.; Peters, B.; Pivovarova-Ramich, O.; Kandil, F.; Michalsen, A.; Breinlinger, C.; Steckhan, N.; Koppold, D.; Dommisch, H.
item type	Journal article
publication year	2025
date	2025
publication title	Journal of Clinical Periodontology
abstract note	Aim: To evaluate the effect of religious Bahá'í dry fasting (BF) or 16:8 time-restricted eating (TRE) compared with a regular diet (CG) on periodontal parameters during a modified experimentally induced gingivitis. Material and Methods: All participants were asked to refrain from oral hygiene (3 sextant) for 9 days (T1–T2) and were followed for a total of 19 days (T3) while adhering to fasting or a regular diet and resuming oral hygiene. The primary outcome was bleeding on probing in the test sextant (BOP_s), Rustogi plaque index (RPI), gingival crevicular fluid (GCF), blood pressure (BP), body weight (BW), HbA1c and C-reactive protein (CRP) were measured (T1–T3) and ANCOVA and post hoc comparison were applied. Results: Sixty-six healthy participants were recruited. Forty-three were randomly assigned to TRE (n = 22) and CG (n = 21), while 23 followed BF, avoiding food and drinks during the day. At T2, BF demonstrated significantly less increase in BOP_s, and GCF increased in CG only. Analysis revealed significant differences in change for BOP_s between BF and CG (−9.48% [−17.18; −1.79]) and BF and TRE (−9.19% [−15.07; −3.32]) as well as for GCF between BF and CG (−0.06 μL [−7.22; −0.66]) and TRE and CG (−0.08 μL [−0.17; −0.00]). Conclusion: This study indicates beneficial effects of different fasting protocols on oral experimental gingivitis and metabolic parameters, but results are limited by randomisation issues and potential bias in the BF group.
pages	681-694
issue	5
volume	52
language	English
manual tags	FASTING; GINGIVITIS; PERIODONTOLOGY

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